What Is The Role of Vinpocetine?

Vinpocetine Powder, derived from the vinca alkaloid vincamine, is a famous medical material for research in the field of cerebrovascular disease. Vinpocetine (ethyl apovincaminate), a synthetic derivative of the vinca alkaloid vincamine, differs by the removal of a hydroxyl group. Vincamine is extracted from either the seeds of Voacanga africana or the leaves of Vinca minor (lesser periwinkle). Vinpocetine has been used in many Asian and European countries to treat cerebrovascular disorders such as stroke and dementia for over three decades. In recent years, this drug as a hot seller for many suppliers. What attracts customers mostly is the high quality. The purity we can provide no less than 99% purity. Except that, we have an incredibly competitive price. If you want to know more about it, just contact Xi'an Sonwnu Biotech Co., Ltd.

vinpocetine molecular formula

Certificate of Analysis

ANALYSIS	SPECIFICATION	RESULT
Apperance	White powder	Complies
Assay	≥99.0%	Complies
Residue On Ignition	≤0.1%	0.04%
Particle Szie	100% through 80 mesh	80 mesh
Loss on drying	≤1%	0.22%
Extract Solvent	Water&Ethanol	Complies
Heavy metal
Cd	≤0.1ppm	0.04ppm
Pb	≤0.1ppm	0.06ppm
As	≤0.2ppm	Complies
Hg	≤0.25ppm	Complies
Total bacteria count	≤1000cfu/g	62cfu/g
Fungi	≤100cfu/g	31cfu/g
Samonella	Negative	Complies
E. Coli	Negative	Complies
Conclusion	This product conforms to international standards

Where To Buy Vinpocetine

Xi'an Sonwu Biotechnology Co., Ltd. has rich experience in the global trade and health industry. Adhere to honesty and quality first. We strictly control the quality of products and choose from raw materials. In addition, we deal with every detail to minimize costs, and then our customers can get cost-effective products. Based on this, customers gave good feedback on our products. So when purchasing pure Vinpocetine Powder, please select Xi'an Songwu Biotechnology Co., Ltd.

Xi'an Sonwu completely makes sure product’s quality, so sample can be supplied. Here is the quantity.

Form	Sample Amount	The Minimum of Quantity
Powder	5g	10g
Bulk Capsules	200 capsules	200 capsules
Bottled Capsules	5 bottles	5 bottles

Customers' Good Comment

Vinpocetine Powder comment

OEM Service

Xi 'an Sonwu can provide the drug in powder but also capsule form.

So any customers could customize capsules they want. And items below can be supplied.

1.Customized capsules shells (size, color, material)

2.Customized bottles(size, color, material, style)

3.Customized packaging(vacuum foil packaging, box, drum)

4.Customized label(paint film, matte film, optical mask)

Vinpocetine Powder-

What is The Mechanism of Action of Vinpocetine

Vinpocetine is an indole alkaloid. Its pharmacological effects: increase cerebral blood flow by inhibiting Ca2+ dependent phosphodiesterase activity, increase the impact of cyclic guanosine, selective relaxation of smooth muscle, increase cerebral blood flow; Improve blood mobility and microcirculation by enhancing erythrocyte deformability, reducing blood viscosity, and inhibiting platelet aggregation.

Improve brain metabolism: increase the oxygen supply of the brain, promote the uptake of glucose in brain tissue, promote the metabolic transformation of monoamine in the brain, inhibit the increase of lactic acid metabolism and ATP content in the ischemic brain, and increase the oxygen dissociation degree of hemoglobin; Increase the anti-hypoxia ability of the brain, inhibit the occurrence of ischemic cerebral vasospasm and the production of lipid peroxide.

Evidence has been obtained that the neuroprotective action vinpocetine is related to the inhibition of operation of voltage-dependent neuronal Na(+)-channels, indirect inhibition of some molecular cascades initiated by the rise of intracellular Ca(2+)-levels, and, to a lesser extent, inhibition of adenosine reuptake. Vinpocetine has been shown to be a selective inhibitor of Ca(2+)-calmodulin-dependent cGMP-PDE. If this inhibition enhances intracellular GMP levels in the vascular smooth muscle leading to reduced resistance of cerebral vessels and an increase of cerebral flow. This effect also beneficially contributes to the neuroprotective action.

Mechanism of action of vinpocetine

Does Vinpocetine Increase Dopamine

Vinpocetine has been implicated in reducing intracellular dopamine concentrations (with an increase in the dopamine metabolite DOPAC) in isolated striatum nerve endings via mechanisms independent of its interaction with sodium channels and increasing external DOPAC concentrations. This increase in DOPAC at the expense of dopamine is known to occur with MAO activators, but this does not appear to be the case with vinpocetine, and impairment of vesicular storage of dopamine is thought to be the cause.

Vinpocetine does not significantly affect the release rate of dopamine into the synapse invoked by high potassium. However, it effectively inhibits the dopamine release caused by sodium channel activators (by its sodium channel blocking ability), glutamate, and methamphetamine.

What Are The Negative Effects of Vinpocetine

The nervous system can be seen with a heavy head, dizziness, occasional drowsiness, and numbness of side limbs. Nausea, vomiting, anorexia, abdominal pain, and diarrhea can be seen in the digestive system. The circulatory system has symptoms such as flushing and dizziness. Leukopenia can be seen in the blood system. The visceral liver reaction showed that AST and ALT were elevated, and alkaline phosphatase was rarely elevated. The renal response indicated that the blood urea nitrogen increased. In severe cases, skin rash, urticaria, pruritus, and other allergic reactions may occur, and the drug should be stopped now. Occasionally, a slight decrease in blood pressure, tachycardia, etc. In addition, you must follow the doctor's advice before taking this drug.

Factory Environment

1. Xi'an Sonwu Biotech Co., Ltd has its own factory, so it has adequate stock. Also, Xi'an Sonwu has a clean and tidy producing department with advanced equipment. With the lead of Xi'an Sonwu, researchers are constantly developing new products to meet customers' needs.
2. Xi'an Sonwu Biotech Co., Ltd has advanced test equipment and professional testers, which all show that Xi'an Sonwu aims to supply accurate and effective data and good service.

factory a

factory b

Certificates

Vinpocetine Powder certificates

Packaging

Vinpocetine Powder packaging

In addition to guaranteeing product quality, the other most vital thing is clients can receive the goods smoothly. So, Xi’an Sonwu supplies all kinds of couriers according to different needs.

Vinpocetine Powder courier