Temozolomide Powder

Temozolomide Chemotherapy
Temozolomide powder is a chemotherapy drug mainly used for newly diagnosed glioblastoma multiforme. It can be used in combination with radiotherapy and can also be used as adjuvant therapy. It has a novel chemical structure and is an imidazopyridine derivative. Temozolomide does not directly play a role. At physiological pH, it is rapidly converted into the active compound MTIC. It is believed that the cytotoxicity of MTIC is mainly due to its DNA alkylation, which occurs primarily at the O6 and N7 positions of guanine. The function of the alkylating agent is to break the DNA chain in cancer cells, allowing cancer cells to crack and rupture. Temozolomide is effective against some of the most common glioblastomas in basic and clinical studies. It is mainly used for malignant gliomas that relapse after conventional treatment, such as glioblastoma multiforme or degenerative astrocytoma. It is also used as a first-line drug for treating metastatic melanoma. Brain metastases caused by other malignancies are also applicable.
Temozolomide is a new oral alkylating agent antineoplastic drug with broad-spectrum anti-bad cell groups activity, can pass through the blood-brain barrier, and has a bioavailability close to 100%. It can effectively treat newly diagnosed and recurrent glioblastoma and anaplastic astrocytoma cell bad cell groups, prolong the survival of patients and are safe and well tolerated. It is the first orally effective imidazopyridine antineoplastic drug and belongs to the second generation of alkylating agents with anti-bad cell group activity. So if you are interested in pure temozolomide, please get in touch with Xi'an' Sonwu.

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Where To Buy Temozolomide
Xi'an Sonwu Biotech Co. ltd. is a manufacturer and distributor with over ten years of experience. It has extensive and stable cooperation with countries worldwide in the Americas, Asia, Europe, and Oceania. Xi'an Sonwu has always insisted on product quality first. Serving every customer well and satisfying every customer is Xi'an Sonwu's pursuit. In addition, Xi'an Sonwu strives to handle every detail to minimize costs and allow customers to get products with high-cost performance. Based on these, customers have given good feedback on the product. So if you are interested in temozolomide, please contact Xi'an Sonwu.
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What Is Temozolomide Used For
1. Glial lesion cells
Glioma is the most common primary brain sarcoma from glial cell lesions in the brain and spinal cord. There are many kinds of glial cells, such as neurogenic cells, astrocytes, embryonic cells, oligodendroglial cells, etc. People collectively call them glial disease cells. Surgical treatment. The effect of temozolomide in treating recurrent glioblastoma multiforme has been confirmed by clinical trials to be safe and effective.
A randomized controlled trial showed that 225 patients with first relapsed glioblastoma multiforme were treated with temozolomide or procarbazine for six months, respectively, and the survival rate and overall survival rate of patients in the temozolomide group were 21% and 60%, respectively. %, significantly higher than the 8% and 44% of the procarbazine group. Temozolomide patients' average progression-free survival time was 2.9 and 7.3 months, respectively, substantially higher than those of the procarbazine group (1.9 and 5.8 months). The trial also conducted health-related quality-of-life assessments in the 3rd and 6th months after the start of treatment. The results also confirmed that more patients in the temozolomide group had improved or maintained their quality of life. Therefore, temozolomide's curative effect and adverse drug reaction on recurrent glioblastoma cells are significantly better than the standard procarbazine.

2. Anaplastic astrocytic cells
Anaplastic astrocytic cells are malignant cells that usually appear in the brain or spinal cord. According to clinical manifestations, epilepsy usually occurs first in adults, and then paralysis, aphasia, mental changes, and finally, increased intracranial pressure appear. The treatment of this kind of malignant cells is complex, and the resection of sarcoma in different parts will be additional, but it cannot be completely resected. Although many patients do not recover very well after surgery after systematic treatment, the average life expectancy of most patients is between 1 and 2. 2-3 years. Temozolomide powder can exert cytotoxicity through the mismatch repair of methylation adducts and finally can achieve the effect of inhibiting brain cell lesions.
 

How Does Temozolomide Work
DNA methylation and mismatch repair failure are currently considered the main mechanisms of TMZ cytotoxicity. Under physiological conditions, TMZ does not require enzyme catalysis. When water molecules act on its positively charged 4th carbon atom, its closed ring opens immediately, releasing carbon dioxide to generate the active product 5-(3-methyl triazine En-1-) imidazole-4-amide (MTIC). MTIC is converted into a cationic methyl diazonium salt, which transfers the methyl group to DNA and degrades it into the final product 5-aminoimidazole-4-carboxamide-(AICA), which is then excreted by the kidneys. The sites of DNA methylation are the 7th nitrogen atom of guanine and the 3rd oxygen atom of adenine. Although methylguanine adducts at the 6th oxygen atom accounted for the tiniest proportion, they played the most critical role in the anti-bad cell group. Although the mismatch repair system can identify the wrongly paired base pairs during the DNA replication process, it cannot find a paired base for the 6th oxygen atom methylguanine, so there is a gap in the sub-strand DNA. The gap gradually accumulates with cell division and finally hinders the replication initiation, so the cells are arrested in the G2/M phase and undergo apoptosis.
TMZ enters the body and is widely distributed throughout the body. It can penetrate the blood-brain barrier and enter the cerebrospinal fluid; it reaches an effective drug concentration in the central nervous system. Its cerebrospinal fluid/plasma drug concentration ratio is close to 30% to 40%. TMZ itself has no direct anti-pathological cell activity. Under physiological conditions, it rapidly undergoes non-enzymatic conversion into the active compound MTIC. MTIC is further decomposed into 5 - Amino-imidazole-4-amide (AIC), and diazomethane is an active alkylating substance. Its cytotoxicity is deemed methylation of DNA, which occurs at the guanine N7 and O6 positions. It acts on the nucleic acid, protein, and peptide nucleophilic regions of diseased cells and works on various stages of dividing bad cell groups.

Is Temozolomide Safe
The main adverse reactions of temozolomide include nausea, vomiting, fatigue, and hematological reactions. Nausea, vomiting, headache, and fatigue occurred most frequently. Usually, NCI general toxicity criteria are mild to moderate and self-limiting, with nausea and vomiting controlled with antiemetics. However, regarding the overall incidence of adverse reactions, the incidence of patients aged 70 years and over is not higher. Other common adverse reactions are fatigue, constipation and headache, dizziness, shortness of breath, hair loss, anemia, fever, and decreased immunity. Temozolomide has little toxicity, but it is generally well tolerated.
 

Factory
1. Xi'an Sonwu Biotech Co., Ltd has its factory to produce, manufacture and store the products, so have adequate Stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu Biotech Co., Ltd strictly controls every step, such as material selection, manufacturing, sample testing, and personnel professionalism. Rigorous data support and after-sales service are provided to ensure each product is escorted.

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Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ
1. Synchronous chemotherapy and radiotherapy period
This product is a daily dose of 75mg/m2 for 42 days while receiving radiotherapy. Then receive six cycles of adjuvant therapy with this product. The drug can be suspended according to the patient's tolerance, but there is no need to reduce the dose. The drug should be discontinued during concurrent chemotherapy according to hematological and non-hematological toxicity criteria.
2. Adjuvant treatment period
Six cycles of adjuvant therapy were performed four weeks after this product's synchronous radiotherapy and chemotherapy period ended. The dose of this product in the first cycle is 150mg/m2/day. Then stop the drug for 23 days. At the beginning of cycle 2, the dose can be increased to 200mg/m2/day. If you do not add the dosage in Cycle 2, you should not add the amount in subsequent cycles. The following processes keep at 200mg/m2 daily except for toxicity.
3. Adult patients
The dose of this product in each 28-day cycle of patients who have not received chemotherapy before is 200mg/m2 per day for five days. The starting dose of this product for patients who have previously received chemotherapy is 150mg/m2/day.
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Email: sales@sonwu.com

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